Lower limb muscle weakness
Weakness of the muscles of the legs.
Also called: Leg weakness, Lower extremity weakness, Lower limb muscle weakness, Lower limb weakness, Muscle weakness in lower limbs.
Conditions associated with lower limb muscle weakness
The following conditions have been associated with lower limb muscle weakness in medical literature. This is informational and not a diagnosis.
Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency
Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency is a medical condition that m...
Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a medical condition that may be associated with various symptoms and signs....
Arachnoid cyst
Arachnoid cyst is a medical condition that may be associated with various symptoms and signs....
Charcot-Marie-Tooth disease type 4B2
Charcot-Marie-Tooth disease type 4B2 is a medical condition that may be associated with various symptoms and s...
Charcot-Marie-Tooth disease, axonal, type 2KK
Charcot-Marie-Tooth disease, axonal, type 2KK is a medical condition that may be associated with various sympt...
Dysferlin-related limb-girdle muscular dystrophy R2
Dysferlin-related limb-girdle muscular dystrophy R2 is a medical condition that may be associated with various...
Fragile X-associated tremor/ataxia syndrome
Fragile X-associated tremor/ataxia syndrome is a medical condition that may be associated with various symptom...
GMPPB-related limb-girdle muscular dystrophy R19
GMPPB-related limb-girdle muscular dystrophy R19 is a medical condition that may be associated with various sy...
GNE myopathy
GNE myopathy is a medical condition that may be associated with various symptoms and signs....
Genetic recurrent myoglobinuria
Genetic recurrent myoglobinuria is a medical condition that may be associated with various symptoms and signs....
Glycogen storage disease due to acid maltase deficiency
Glycogen storage disease due to acid maltase deficiency is a medical condition that may be associated with var...
Hereditary motor and sensory neuropathy, Okinawa type
Hereditary motor and sensory neuropathy, Okinawa type is a medical condition that may be associated with vario...
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
Homocystinuria due to methylene tetrahydrofolate reductase deficiency is a medical condition that may be assoc...
IgG4-related pachymeningitis
IgG4-related pachymeningitis is a medical condition that may be associated with various symptoms and signs....
Lipodystrophy, familial partial, type 7
Lipodystrophy, familial partial, type 7 is a medical condition that may be associated with various symptoms an...
MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome is a medical condition that may ...
Meningioma
Meningioma is a medical condition that may be associated with various symptoms and signs....
Mitochondrial complex IV deficiency, nuclear type 2
Mitochondrial complex IV deficiency, nuclear type 2 is a medical condition that may be associated with various...
Mitochondrial trifunctional protein deficiency
Mitochondrial trifunctional protein deficiency is a medical condition that may be associated with various symp...
Parkes Weber syndrome
Parkes Weber syndrome is a medical condition that may be associated with various symptoms and signs....
Peripheral primitive neuroectodermal tumor
Peripheral primitive neuroectodermal tumor is a medical condition that may be associated with various symptoms...
Poliomyelitis
Poliomyelitis is a medical condition that may be associated with various symptoms and signs....
Spinal fast-flow vascular malformation
Spinal fast-flow vascular malformation is a medical condition that may be associated with various symptoms and...
Spinal muscular atrophy-progressive myoclonic epilepsy syndrome
Spinal muscular atrophy-progressive myoclonic epilepsy syndrome is a medical condition that may be associated ...
Superficial siderosis
Superficial siderosis is a medical condition that may be associated with various symptoms and signs....
Tay-Sachs disease
Tay-Sachs disease is a medical condition that may be associated with various symptoms and signs....
Thyrotoxic periodic paralysis
Thyrotoxic periodic paralysis is a medical condition that may be associated with various symptoms and signs....
adrenoleukodystrophy
A peroxisomal disorder resulting in cerebral demyelination, axonal dysfunction in the spinal cord leading to s...
combined oxidative phosphorylation deficiency 54
combined oxidative phosphorylation deficiency 54 is a medical condition that may be associated with various sy...
congenital myasthenic syndrome 1A
Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the CHRNA1 gene....
congenital myopathy 23
Any nemaline myopathy in which the cause of the disease is a mutation in the TPM2 gene....
developmental delay with or without epilepsy
developmental delay with or without epilepsy is a medical condition that may be associated with various sympto...
frontotemporal dementia and/or amyotrophic lateral sclerosis 6
Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the VCP gene....
hereditary spastic paraplegia 12
Autosomal dominant spastic paraplegia type 12 is a pure form of hereditary spastic paraplegia characterized by...
hereditary spastic paraplegia 7
Autosomal recessive spastic paraplegia type 7 is a form of hereditary spastic paraplegia characterized by an o...
intellectual disability, autosomal dominant 42
Any autosomal dominant intellectual disability in which the cause of the disease is a heterozygous mutation in...
mitochondrial DNA depletion syndrome 6 (hepatocerebral type)
mitochondrial DNA depletion syndrome 6 (hepatocerebral type) is a medical condition that may be associated wit...
multiple mitochondrial dysfunctions syndrome 9b
A mitochondrial dysfunction syndrome in which the cause of the disease is a mutation in the FDXR gene. It is c...
myofibrillar myopathy 2
Any autosomal dominant distal myopathy in which the cause of the disease is a mutation in the CRYAB gene....
myofibrillar myopathy 6
Selcen type muscular dystrophy is characterized by progressive limb and axial muscle weakness associated with ...
Tests providers may use to investigate lower limb muscle weakness
When investigating lower limb muscle weakness, a healthcare provider may order one or more of the following laboratory tests. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Symptoms commonly seen alongside lower limb muscle weakness
Dysphagia
Difficulty in swallowing....
Fatigue
A subjective feeling of tiredness characterized by a lack of energy and motivation....
Fever
Body temperature elevated above the normal range....
Headache
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve....
Muscle weakness
Reduced strength of muscles....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
When to seek care
Seek care from a qualified healthcare provider if lower limb muscle weakness is severe, persistent, worsening, or accompanied by concerning symptoms. If you think you have a medical emergency, call your local emergency number immediately.
Frequently Asked Questions
What does the symptom lower limb muscle weakness mean?
Lower limb muscle weakness is a health sign or symptom described in medical literature. Weakness of the muscles of the legs.
Which conditions are associated with lower limb muscle weakness?
Lower limb muscle weakness has been reported in association with 49 conditions in the medical literature we index, including Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency, Amyotrophic lateral sclerosis, Arachnoid cyst, Charcot-Marie-Tooth disease type 4B2, Charcot-Marie-Tooth disease, axonal, type 2KK. These associations do not mean you have any of these conditions.
Should I see a doctor about lower limb muscle weakness?
You should discuss any persistent or concerning symptoms with a qualified healthcare provider. This website does not provide diagnosis. If you have severe symptoms or signs of a medical emergency, seek care immediately.