hereditary spastic paraplegia 12
Autosomal dominant spastic paraplegia type 12 is a pure form of hereditary spastic paraplegia characterized by a childhood- to adulthood-onset of slowly progressive lower limb spasticity and hyperreflexia of lower extremities, extensor plantar reflexes, distal sensory impairment, variable urinary dysfunction and pes cavus.
Also known as: RTN2 hereditary spastic paraplegia, SPG12, autosomal dominant spastic paraplegia type 12, hereditary spastic paraplegia caused by mutation in RTN2, hereditary spastic paraplegia type 12, spastic paraplegia 12, spastic paraplegia 12, autosomal dominant.
Category: General
Symptoms associated with hereditary spastic paraplegia 12
The following symptoms have been associated with hereditary spastic paraplegia 12 in medical literature. Not everyone experiences the same symptoms.
Chronic constipation
Constipation for longer than three months with fewer than 3 bowel movements per week, straining, lumpy or hard...
Diplopia
Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision...
Dysphagia
Difficulty in swallowing....
Lower limb muscle weakness
Weakness of the muscles of the legs....
Myalgia
Pain in muscle....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
Urinary incontinence
Loss of the ability to control the urinary bladder leading to involuntary urination....
Tests used to investigate hereditary spastic paraplegia 12
Healthcare providers may order these tests when evaluating hereditary spastic paraplegia 12. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Conditions with overlapping symptoms
These conditions share symptoms with hereditary spastic paraplegia 12, which is why a clinical evaluation is important.
Arachnoid cyst
Arachnoid cyst is a medical condition that may be associated with various symptoms and signs....
Encephalitis lethargica
Encephalitis lethargica is a medical condition that may be associated with various symptoms and signs....
IgG4-related pachymeningitis
IgG4-related pachymeningitis is a medical condition that may be associated with various symptoms and signs....
PPFIA3-related neurodevelopmental disorder
A neurodevelopmental disorder caused by variation in the PPFIA3 gene. This disorder is characterised by develo...
mitochondrial DNA depletion syndrome 6 (hepatocerebral type)
mitochondrial DNA depletion syndrome 6 (hepatocerebral type) is a medical condition that may be associated wit...
multiple mitochondrial dysfunctions syndrome 9b
A mitochondrial dysfunction syndrome in which the cause of the disease is a mutation in the FDXR gene. It is c...
Frequently Asked Questions
What is hereditary spastic paraplegia 12?
hereditary spastic paraplegia 12 is a health condition described in medical literature. Autosomal dominant spastic paraplegia type 12 is a pure form of hereditary spastic paraplegia characterized by a childhood- to adulthood-onset of slowly progressive lower limb spasticity and hyperreflexia of lower extremities, extensor plantar reflexes, distal sensory impairment, variable urinary dysfunction and pes cavus.
What are the symptoms of hereditary spastic paraplegia 12?
hereditary spastic paraplegia 12 is associated with 7 symptoms in the medical literature we index, including Chronic constipation, Diplopia, Dysphagia, Lower limb muscle weakness, Myalgia, Seizure. Symptoms vary widely between individuals.
How is hereditary spastic paraplegia 12 diagnosed or investigated?
A healthcare provider may use a combination of medical history, physical examination, and tests. Common tests associated with hereditary spastic paraplegia 12 include CBC with Differential, Comprehensive Metabolic Panel (CMP), Urinalysis. This information is educational, not a diagnosis.
Is SymptomDatabase.com diagnosing me?
No. SymptomDatabase.com does not provide diagnosis. If you are concerned you may have hereditary spastic paraplegia 12, please discuss your symptoms with a qualified healthcare provider.