Unexplained fevers
Episodes of fever for which no infectious cause can be identified.
Also called: Unexplained fevers.
Conditions associated with unexplained fevers
The following conditions have been associated with unexplained fevers in medical literature. This is informational and not a diagnosis.
Aicardi-Goutières syndrome
Aicardi-Goutières syndrome is a medical condition that may be associated with various symptoms and signs....
Infantile Krabbe disease
Infantile Krabbe disease is a medical condition that may be associated with various symptoms and signs....
Severe generalized junctional epidermolysis bullosa
Severe generalized junctional epidermolysis bullosa is a medical condition that may be associated with various...
Simple cryoglobulinemia
Simple cryoglobulinemia is a medical condition that may be associated with various symptoms and signs....
systemic lupus erythematosus 18
Any systemic lupus erythematosus in which the cause of the disease is a variation in the PLD4 gene....
Tests providers may use to investigate unexplained fevers
When investigating unexplained fevers, a healthcare provider may order one or more of the following laboratory tests. Test selection is a clinical decision made by a qualified professional.
ANA (Antinuclear Antibodies)
Screens for autoimmune diseases such as lupus....
Anti-dsDNA Antibodies
Supports diagnosis and monitoring of systemic lupus erythematosus....
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Symptoms commonly seen alongside unexplained fevers
Constipation
Infrequent or difficult evacuation of feces....
Fatigue
A subjective feeling of tiredness characterized by a lack of energy and motivation....
Headache
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve....
Muscle weakness
Reduced strength of muscles....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
Vomiting
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic...
When to seek care
Seek care from a qualified healthcare provider if unexplained fevers is severe, persistent, worsening, or accompanied by concerning symptoms. If you think you have a medical emergency, call your local emergency number immediately.
Frequently Asked Questions
What does the symptom unexplained fevers mean?
Unexplained fevers is a health sign or symptom described in medical literature. Episodes of fever for which no infectious cause can be identified.
Which conditions are associated with unexplained fevers?
Unexplained fevers has been reported in association with 5 conditions in the medical literature we index, including Aicardi-Goutières syndrome, Infantile Krabbe disease, Severe generalized junctional epidermolysis bullosa, Simple cryoglobulinemia, systemic lupus erythematosus 18. These associations do not mean you have any of these conditions.
Should I see a doctor about unexplained fevers?
You should discuss any persistent or concerning symptoms with a qualified healthcare provider. This website does not provide diagnosis. If you have severe symptoms or signs of a medical emergency, seek care immediately.