Proximal muscle weakness
A lack of strength of the proximal muscles.
Also called: Muscle weakness, proximal, Proximal limb muscle weakness, Proximal limb weakness, Weakness in muscles of upper arms and upper legs, Proximal neurogenic muscle weakness.
Conditions associated with proximal muscle weakness
The following conditions have been associated with proximal muscle weakness in medical literature. This is informational and not a diagnosis.
Autosomal dominant Charcot-Marie-Tooth disease type 2Y
Autosomal dominant Charcot-Marie-Tooth disease type 2Y is a medical condition that may be associated with vari...
Autosomal dominant Charcot-Marie-Tooth disease type 2Z
Autosomal dominant Charcot-Marie-Tooth disease type 2Z is a medical condition that may be associated with vari...
Autosomal recessive progressive external ophthalmoplegia
Autosomal recessive progressive external ophthalmoplegia is a medical condition that may be associated with va...
Bethlem myopathy 1A
Bethlem myopathy 1A is a medical condition that may be associated with various symptoms and signs....
Brown-Vialetto-van Laere syndrome 1
Any Brown-Vialetto-van Laere syndrome in which the cause of the disease is a mutation in the SLC52A3 gene....
Carey-Fineman-Ziter syndrome 1
A rare condition characterized by the association of hypotonia, Moebius sequence (bilateral congenital facial ...
Centronuclear myopathy 1
Centronuclear myopathy 1 is a medical condition that may be associated with various symptoms and signs....
Classical-like Ehlers-Danlos syndrome type 1
Classical-like Ehlers-Danlos syndrome type 1 is a medical condition that may be associated with various sympto...
Congenital multicore myopathy with external ophthalmoplegia
Congenital multicore myopathy with external ophthalmoplegia is a medical condition that may be associated with...
Congenital myasthenic syndrome
Congenital myasthenic syndrome is a medical condition that may be associated with various symptoms and signs....
Cushing syndrome due to bilateral macronodular adrenocortical disease
Cushing syndrome due to bilateral macronodular adrenocortical disease is a medical condition that may be assoc...
Dermatomyositis
Dermatomyositis is a medical condition that may be associated with various symptoms and signs....
Distal myotilinopathy
Distal myotilinopathy is a medical condition that may be associated with various symptoms and signs....
Frontotemporal dementia with motor neuron disease
Frontotemporal dementia with motor neuron disease is a medical condition that may be associated with various s...
Glycogen storage disease 0, muscle
Glycogen storage disease 0, muscle is a medical condition that may be associated with various symptoms and sig...
Glycogen storage disease II
Glycogen storage disease II is a medical condition that may be associated with various symptoms and signs....
Glycogen storage disease due to acid maltase deficiency, infantile onset
Glycogen storage disease due to acid maltase deficiency, infantile onset is a medical condition that may be as...
Hereditary myopathy with early respiratory failure
Hereditary myopathy with early respiratory failure is a medical condition that may be associated with various ...
Isolated succinate-CoQ reductase deficiency
Isolated succinate-CoQ reductase deficiency is a medical condition that may be associated with various symptom...
MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome is a medical condition that may ...
Medium chain acyl-CoA dehydrogenase deficiency
Medium chain acyl-CoA dehydrogenase deficiency is a medical condition that may be associated with various symp...
Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome
Mitochondrial myopathy-cerebellar ataxia-pigmentary retinopathy syndrome is a medical condition that may be as...
Multiple acyl-CoA dehydrogenase deficiency
Multiple acyl-CoA dehydrogenase deficiency is a medical condition that may be associated with various symptoms...
Myopathy, distal, 1
Myopathy, distal, 1 is a medical condition that may be associated with various symptoms and signs....
Nemaline myopathy 3
Nemaline myopathy 3 is a medical condition that may be associated with various symptoms and signs....
Polymyositis
Polymyositis is a medical condition that may be associated with various symptoms and signs....
Presynaptic congenital myasthenic syndromes
Presynaptic congenital myasthenic syndromes is a medical condition that may be associated with various symptom...
Proximal myotonic myopathy
Proximal myotonic myopathy is a medical condition that may be associated with various symptoms and signs....
Proximal spinal muscular atrophy
Proximal spinal muscular atrophy is a medical condition that may be associated with various symptoms and signs...
Pure mitochondrial myopathy
Pure mitochondrial myopathy is a medical condition that may be associated with various symptoms and signs....
Sandhoff disease, juvenile form
Sandhoff disease, juvenile form is a medical condition that may be associated with various symptoms and signs....
Sarcoidosis
Sarcoidosis is a medical condition that may be associated with various symptoms and signs....
Scleromyxedema
Scleromyxedema is a medical condition that may be associated with various symptoms and signs....
Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome
Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome is a medical condition that may be associated w...
Steinert myotonic dystrophy
Steinert myotonic dystrophy is a medical condition that may be associated with various symptoms and signs....
Stormorken syndrome
Stormorken-Sjaastad-Langslet syndrome is characterized by thrombocytopathy, asplenia, miosis, muscle fatigue, ...
Synaptic congenital myasthenic syndrome
Synaptic congenital myasthenic syndrome is a medical condition that may be associated with various symptoms an...
autosomal recessive limb-girdle muscular dystrophy type 2H
Autosomal recessive limb-girdle muscular dystrophy type 2H (LGMD2H) is a mild subtype of autosomal recessive l...
congenital generalized lipodystrophy type 4
Any congenital generalized lipodystrophy in which the cause of the disease is a mutation in the CAVIN1 gene....
congenital muscular dystrophy due to LMNA mutation
Congenital muscular dystrophy due to LMNA mutation is a rare congenital muscular dystrophy characterized by pr...
Tests providers may use to investigate proximal muscle weakness
When investigating proximal muscle weakness, a healthcare provider may order one or more of the following laboratory tests. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Symptoms commonly seen alongside proximal muscle weakness
Dysphagia
Difficulty in swallowing....
Fatigue
A subjective feeling of tiredness characterized by a lack of energy and motivation....
Fever
Body temperature elevated above the normal range....
Headache
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve....
Muscle weakness
Reduced strength of muscles....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
When to seek care
Seek care from a qualified healthcare provider if proximal muscle weakness is severe, persistent, worsening, or accompanied by concerning symptoms. If you think you have a medical emergency, call your local emergency number immediately.
Frequently Asked Questions
What does the symptom proximal muscle weakness mean?
Proximal muscle weakness is a health sign or symptom described in medical literature. A lack of strength of the proximal muscles.
Which conditions are associated with proximal muscle weakness?
Proximal muscle weakness has been reported in association with 66 conditions in the medical literature we index, including Autosomal dominant Charcot-Marie-Tooth disease type 2Y, Autosomal dominant Charcot-Marie-Tooth disease type 2Z, Autosomal recessive progressive external ophthalmoplegia, Bethlem myopathy 1A, Brown-Vialetto-van Laere syndrome 1. These associations do not mean you have any of these conditions.
Should I see a doctor about proximal muscle weakness?
You should discuss any persistent or concerning symptoms with a qualified healthcare provider. This website does not provide diagnosis. If you have severe symptoms or signs of a medical emergency, seek care immediately.