Proximal lower limb muscle weakness
A lack of strength of the proximal muscles of the legs.
Also called: Muscle weakness, proximal, lower limbs, Proximal muscle weakness in lower limbs.
Conditions associated with proximal lower limb muscle weakness
The following conditions have been associated with proximal lower limb muscle weakness in medical literature. This is informational and not a diagnosis.
Acute intermittent porphyria
Acute intermittent porphyria is a medical condition that may be associated with various symptoms and signs....
Adenylosuccinate synthetase-like 1-related distal myopathy
Adenylosuccinate synthetase-like 1-related distal myopathy is a medical condition that may be associated with ...
Anoctamin-5-related limb-girdle muscular dystrophy R12
Anoctamin-5-related limb-girdle muscular dystrophy R12 is a medical condition that may be associated with vari...
Autosomal dominant Charcot-Marie-Tooth disease type 2Y
Autosomal dominant Charcot-Marie-Tooth disease type 2Y is a medical condition that may be associated with vari...
Autosomal dominant Charcot-Marie-Tooth disease type 2Z
Autosomal dominant Charcot-Marie-Tooth disease type 2Z is a medical condition that may be associated with vari...
Autosomal dominant centronuclear myopathy
Autosomal dominant centronuclear myopathy is a medical condition that may be associated with various symptoms ...
Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
Autosomal recessive Charcot-Marie-Tooth disease with hoarseness is a medical condition that may be associated ...
Charcot-Marie-Tooth disease type 1F
Charcot-Marie-Tooth disease type 1F is a medical condition that may be associated with various symptoms and si...
Charcot-Marie-Tooth disease type 4B2
Charcot-Marie-Tooth disease type 4B2 is a medical condition that may be associated with various symptoms and s...
Charcot-Marie-tooth disease, axonal, type 2JJ
Charcot-Marie-tooth disease, axonal, type 2JJ is a medical condition that may be associated with various sympt...
Dysferlin-related limb-girdle muscular dystrophy R2
Dysferlin-related limb-girdle muscular dystrophy R2 is a medical condition that may be associated with various...
Emery-Dreifuss muscular dystrophy 2, autosomal dominant
Emery-Dreifuss muscular dystrophy inherited in an autosomal dominant pattern and caused by mutations in the LM...
FLNC-related handgrip and calf weakness-distal myopathy
FLNC-related handgrip and calf weakness-distal myopathy is a medical condition that may be associated with var...
Hereditary coproporphyria
Hereditary coproporphyria is a medical condition that may be associated with various symptoms and signs....
Immune-mediated necrotizing myopathy
Immune-mediated necrotizing myopathy is a medical condition that may be associated with various symptoms and s...
Laing distal myopathy
Laing distal myopathy is a medical condition that may be associated with various symptoms and signs....
Miyoshi myopathy
Miyoshi myopathy is a medical condition that may be associated with various symptoms and signs....
Multiple congenital anomalies-hypotonia-seizures syndrome
Multiple congenital anomalies-hypotonia-seizures syndrome is a medical condition that may be associated with v...
Wilson disease
Wilson disease is a medical condition that may be associated with various symptoms and signs....
congenital myopathy 22A, classic
congenital myopathy 22A, classic is a medical condition that may be associated with various symptoms and signs...
congenital myopathy 25
congenital myopathy 25 is a medical condition that may be associated with various symptoms and signs....
congenital myopathy 26
congenital myopathy 26 is a medical condition that may be associated with various symptoms and signs....
frontotemporal dementia and/or amyotrophic lateral sclerosis 6
Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the VCP gene....
muscular dystrophy, limb-girdle, autosomal recessive 28
muscular dystrophy, limb-girdle, autosomal recessive 28 is a medical condition that may be associated with var...
muscular dystrophy, limb-girdle, autosomal recessive 29
muscular dystrophy, limb-girdle, autosomal recessive 29 is a medical condition that may be associated with var...
myopathy, distal, 7, adult-onset, X-linked
myopathy, distal, 7, adult-onset, X-linked is a medical condition that may be associated with various symptoms...
myopathy, myofibrillar, 13, with rimmed vacuoles
A rare genetic neuromuscular disease caused by a mutation in HSPB8 gene, characterized by length-dependent axo...
neuronopathy, distal hereditary motor, autosomal recessive 11, with spasticity
neuronopathy, distal hereditary motor, autosomal recessive 11, with spasticity is a medical condition that may...
neuronopathy, distal hereditary motor, autosomal recessive 7
neuronopathy, distal hereditary motor, autosomal recessive 7 is a medical condition that may be associated wit...
oculopharyngeal muscular dystrophy 2
oculopharyngeal muscular dystrophy 2 is a medical condition that may be associated with various symptoms and s...
oculopharyngodistal myopathy 5
oculopharyngodistal myopathy 5 is a medical condition that may be associated with various symptoms and signs....
Tests providers may use to investigate proximal lower limb muscle weakness
When investigating proximal lower limb muscle weakness, a healthcare provider may order one or more of the following laboratory tests. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Symptoms commonly seen alongside proximal lower limb muscle weakness
Depression
Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these m...
Dysphagia
Difficulty in swallowing....
Fatigue
A subjective feeling of tiredness characterized by a lack of energy and motivation....
Fever
Body temperature elevated above the normal range....
Muscle weakness
Reduced strength of muscles....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
When to seek care
Seek care from a qualified healthcare provider if proximal lower limb muscle weakness is severe, persistent, worsening, or accompanied by concerning symptoms. If you think you have a medical emergency, call your local emergency number immediately.
Frequently Asked Questions
What does the symptom proximal lower limb muscle weakness mean?
Proximal lower limb muscle weakness is a health sign or symptom described in medical literature. A lack of strength of the proximal muscles of the legs.
Which conditions are associated with proximal lower limb muscle weakness?
Proximal lower limb muscle weakness has been reported in association with 31 conditions in the medical literature we index, including Acute intermittent porphyria, Adenylosuccinate synthetase-like 1-related distal myopathy, Anoctamin-5-related limb-girdle muscular dystrophy R12, Autosomal dominant Charcot-Marie-Tooth disease type 2Y, Autosomal dominant Charcot-Marie-Tooth disease type 2Z. These associations do not mean you have any of these conditions.
Should I see a doctor about proximal lower limb muscle weakness?
You should discuss any persistent or concerning symptoms with a qualified healthcare provider. This website does not provide diagnosis. If you have severe symptoms or signs of a medical emergency, seek care immediately.