Mitochondrial swelling
The mitochondrial matrix refers to the substance occupying the space enclosed by the inner membrane of a mitochondrion, which contains enzymes, DNA, granules, and inclusions of protein crystals, glycogen, and lipid. Mitochondrial swelling refers to an increase in size of the mitochondrial matrix. This phenomenon is thought to be related to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix. Mitochondrial swelling may distend the outer membrane until it ruptures.
Conditions associated with mitochondrial swelling
The following conditions have been associated with mitochondrial swelling in medical literature. This is informational and not a diagnosis.
MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome is a medical condition that may ...
mitochondrial complex I deficiency, nuclear type 29
mitochondrial complex I deficiency, nuclear type 29 is a medical condition that may be associated with various...
Tests providers may use to investigate mitochondrial swelling
When investigating mitochondrial swelling, a healthcare provider may order one or more of the following laboratory tests. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Symptoms commonly seen alongside mitochondrial swelling
Failure to thrive
Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm....
Fatigue
A subjective feeling of tiredness characterized by a lack of energy and motivation....
Muscle weakness
Reduced strength of muscles....
Myalgia
Pain in muscle....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
Vomiting
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic...
When to seek care
Seek care from a qualified healthcare provider if mitochondrial swelling is severe, persistent, worsening, or accompanied by concerning symptoms. If you think you have a medical emergency, call your local emergency number immediately.
Frequently Asked Questions
What does the symptom mitochondrial swelling mean?
Mitochondrial swelling is a health sign or symptom described in medical literature. The mitochondrial matrix refers to the substance occupying the space enclosed by the inner membrane of a mitochondrion, which contains enzymes, DNA, granules, and inclusions of protein crystals, glycogen, and lipid. Mitochondrial swelling refers to an increase in size of the mitochondrial matrix. This phenomenon is thought to be related to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix. Mitochondrial swelling may distend the outer membrane until it ruptures.
Which conditions are associated with mitochondrial swelling?
Mitochondrial swelling has been reported in association with 2 conditions in the medical literature we index, including MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome, mitochondrial complex I deficiency, nuclear type 29. These associations do not mean you have any of these conditions.
Should I see a doctor about mitochondrial swelling?
You should discuss any persistent or concerning symptoms with a qualified healthcare provider. This website does not provide diagnosis. If you have severe symptoms or signs of a medical emergency, seek care immediately.