Limb muscle weakness
Reduced strength and weakness of the muscles of the arms and legs.
Also called: Limb muscle weakness, Limb weakness.
Conditions associated with limb muscle weakness
The following conditions have been associated with limb muscle weakness in medical literature. This is informational and not a diagnosis.
Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy is a medical condition th...
Autosomal dominant progressive external ophthalmoplegia
Autosomal dominant progressive external ophthalmoplegia is a medical condition that may be associated with var...
Bickerstaff brainstem encephalitis
Bickerstaff brainstem encephalitis is a medical condition that may be associated with various symptoms and sig...
Biotinidase deficiency
Biotinidase deficiency is a medical condition that may be associated with various symptoms and signs....
Brown-Vialetto-van Laere syndrome 2
Any Brown-Vialetto-van Laere syndrome in which the cause of the disease is a mutation in the SLC52A2 gene....
Charcot-Marie-Tooth disease type 1E
A rare subtype of CMT1 characterized by a variable clinical presentation. Onset within the first two years of ...
Chiari malformation type I
Arnold-Chiari malformation type I is a central nervous system malformation characterized by caudal displacemen...
Cryptococcosis
Cryptococcosis is a medical condition that may be associated with various symptoms and signs....
Emery-Dreifuss muscular dystrophy 2, autosomal dominant
Emery-Dreifuss muscular dystrophy inherited in an autosomal dominant pattern and caused by mutations in the LM...
Glycogen storage disease II
Glycogen storage disease II is a medical condition that may be associated with various symptoms and signs....
Morimoto-Ryu-Malicdan neuromuscular syndrome
Morimoto-Ryu-Malicdan neuromuscular syndrome is a medical condition that may be associated with various sympto...
Myasthenia gravis
Myasthenia gravis is a medical condition that may be associated with various symptoms and signs....
Nemaline myopathy 3
Nemaline myopathy 3 is a medical condition that may be associated with various symptoms and signs....
Porphyria due to ALA dehydratase deficiency
Porphyria due to ALA dehydratase deficiency is a medical condition that may be associated with various symptom...
Progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy is a medical condition that may be associated with various symptoms...
Riboflavin transporter deficiency
Riboflavin transporter deficiency is a medical condition that may be associated with various symptoms and sign...
Wilson disease
A very rare inherited multisystemic disease presenting non-specific neurological, hepatic, psychiatric or osse...
congenital myasthenic syndrome 4A
A congenital myasthenic syndrome characterized by postsynaptic neuromuscular junction defects, early-onset pro...
congenital myasthenic syndrome 5
Congenital myasthenic syndrome caused by mutation(s) in the COLQ gene, encoding acetylcholinesterase collageni...
congenital myopathy 10b, mild variant
congenital myopathy 10b, mild variant is a medical condition that may be associated with various symptoms and ...
congenital myopathy 22A, classic
congenital myopathy 22A, classic is a medical condition that may be associated with various symptoms and signs...
congenital myopathy 23
Any nemaline myopathy in which the cause of the disease is a mutation in the TPM2 gene....
frontotemporal dementia and/or amyotrophic lateral sclerosis 6
Any amyotrophic lateral sclerosis in which the cause of the disease is a mutation in the VCP gene....
hypotonia, infantile, with psychomotor retardation and characteristic facies 3
A rare, genetic, syndromic intellectual disability characterized by usually profound intellectual disability w...
inclusion body myopathy with Paget disease of bone and frontotemporal dementia type 1
A rare autosomal dominant inherited disorder caused by mutations in the VCP gene. It can affect the muscles, b...
mitochondrial dna depletion syndrome 21
mitochondrial dna depletion syndrome 21 is a medical condition that may be associated with various symptoms an...
myasthenic syndrome, congenital, 1B, fast-channel
A congenital myasthenic syndrome characterized by defects in postsynaptic neuromuscular junctions with early-o...
nemaline myopathy 2
An autosomal recessive inherited myopathy caused by mutations in the NEB gene. It is characterized by generali...
nemaline myopathy 7
Any nemaline myopathy in which the cause of the disease is a mutation in the CFL2 gene....
neurodegeneration with ataxia and late-onset optic atrophy
neurodegeneration with ataxia and late-onset optic atrophy is a medical condition that may be associated with ...
oculopharyngeal muscular dystrophy 2
oculopharyngeal muscular dystrophy 2 is a medical condition that may be associated with various symptoms and s...
oculopharyngodistal myopathy 3
oculopharyngodistal myopathy 3 is a medical condition that may be associated with various symptoms and signs....
progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1
Any autosomal dominant progressive external ophthalmoplegia in which the cause of the disease is a mutation in...
progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 3
Any progressive external ophthalmoplegia with mitochondrial DNA deletions in which the cause of the disease is...
progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 4
Any progressive external ophthalmoplegia with mitochondrial DNA deletions in which the cause of the disease is...
progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6
progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6 is a medical cond...
spinocerebellar ataxia 52
spinocerebellar ataxia 52 is a medical condition that may be associated with various symptoms and signs....
Tests providers may use to investigate limb muscle weakness
When investigating limb muscle weakness, a healthcare provider may order one or more of the following laboratory tests. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Myasthenia Gravis Mg Lab Test
An acetylcholine receptor (AChR) antibody test is used to help diagnose Myasthenia Gravis (MG). AChR binding a...
Symptoms commonly seen alongside limb muscle weakness
Dysphagia
Difficulty in swallowing....
Fatigue
A subjective feeling of tiredness characterized by a lack of energy and motivation....
Fever
Body temperature elevated above the normal range....
Headache
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve....
Muscle weakness
Reduced strength of muscles....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
When to seek care
Seek care from a qualified healthcare provider if limb muscle weakness is severe, persistent, worsening, or accompanied by concerning symptoms. If you think you have a medical emergency, call your local emergency number immediately.
Frequently Asked Questions
What does the symptom limb muscle weakness mean?
Limb muscle weakness is a health sign or symptom described in medical literature. Reduced strength and weakness of the muscles of the arms and legs.
Which conditions are associated with limb muscle weakness?
Limb muscle weakness has been reported in association with 37 conditions in the medical literature we index, including Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy, Autosomal dominant progressive external ophthalmoplegia, Bickerstaff brainstem encephalitis, Biotinidase deficiency, Brown-Vialetto-van Laere syndrome 2. These associations do not mean you have any of these conditions.
Should I see a doctor about limb muscle weakness?
You should discuss any persistent or concerning symptoms with a qualified healthcare provider. This website does not provide diagnosis. If you have severe symptoms or signs of a medical emergency, seek care immediately.