Generalized myoclonic seizure
A generalized myoclonic seizure is a type of generalized motor seizure characterized by bilateral, sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.
Also called: Generalised epileptic myoclonus, Generalised myoclonic seizure, Generalised myoclonic seizures, Generalized epileptic myoclonus, Generalized myoclonic seizures, Myoclonus seizures, Myoclonic epilepsy, progressive.
Conditions associated with generalized myoclonic seizure
The following conditions have been associated with generalized myoclonic seizure in medical literature. This is informational and not a diagnosis.
3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form
3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form is a medical condition that may be associ...
Alacrimia-choreoathetosis-liver dysfunction syndrome
Alacrimia-choreoathetosis-liver dysfunction syndrome is a medical condition that may be associated with variou...
Angelman syndrome
Angelman syndrome is a medical condition that may be associated with various symptoms and signs....
Bilateral generalized polymicrogyria
Bilateral generalized polymicrogyria is a medical condition that may be associated with various symptoms and s...
Bilateral polymicrogyria
Bilateral polymicrogyria is a medical condition that may be associated with various symptoms and signs....
Biotinidase deficiency
Biotinidase deficiency is a medical condition that may be associated with various symptoms and signs....
Combined oxidative phosphorylation defect type 27
Combined oxidative phosphorylation defect type 27 is a medical condition that may be associated with various s...
DNM1L-related encephalopathy due to mitochondrial and peroxisomal fission defect
DNM1L-related encephalopathy due to mitochondrial and peroxisomal fission defect is a medical condition that m...
DPAGT1-CDG
DPAGT1-CDG is a medical condition that may be associated with various symptoms and signs....
DPM1-CDG
DPM1-CDG is a medical condition that may be associated with various symptoms and signs....
DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion is a medical condition that...
Dravet syndrome
Dravet syndrome is a medical condition that may be associated with various symptoms and signs....
Early infantile developmental and epileptic encephalopathy
Early infantile developmental and epileptic encephalopathy is a medical condition that may be associated with ...
Epilepsy with eyelid myoclonia
Epilepsy with eyelid myoclonia is a medical condition that may be associated with various symptoms and signs....
Epilepsy with myoclonic-atonic seizures
Epilepsy with myoclonic-atonic seizures is a medical condition that may be associated with various symptoms an...
Familial infantile myoclonic epilepsy
Familial infantile myoclonic epilepsy is a medical condition that may be associated with various symptoms and ...
Folinic acid-responsive seizures
Folinic acid-responsive seizures is a medical condition that may be associated with various symptoms and signs...
Gaucher disease
Gaucher disease is a medical condition that may be associated with various symptoms and signs....
Genetic epilepsy with febrile seizure plus
Genetic epilepsy with febrile seizure plus is a medical condition that may be associated with various symptoms...
Homocystinuria due to methylene tetrahydrofolate reductase deficiency
Homocystinuria due to methylene tetrahydrofolate reductase deficiency is a medical condition that may be assoc...
Infantile Krabbe disease
Infantile Krabbe disease is a medical condition that may be associated with various symptoms and signs....
Isolated succinate-CoQ reductase deficiency
Isolated succinate-CoQ reductase deficiency is a medical condition that may be associated with various symptom...
Krabbe disease
Krabbe disease is a medical condition that may be associated with various symptoms and signs....
Lafora disease
Lafora disease is a medical condition that may be associated with various symptoms and signs....
Lennox-Gastaut syndrome
Lennox-Gastaut syndrome is a medical condition that may be associated with various symptoms and signs....
Lissencephaly due to LIS1 mutation
Lissencephaly due to LIS1 mutation is a medical condition that may be associated with various symptoms and sig...
Mitochondrial DNA-associated Leigh syndrome
Mitochondrial DNA-associated Leigh syndrome is a medical condition that may be associated with various symptom...
PCDH19 clustering epilepsy
PCDH19 clustering epilepsy is a medical condition that may be associated with various symptoms and signs....
Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome
Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndro...
STXBP1-related encephalopathy
STXBP1-related encephalopathy is a medical condition that may be associated with various symptoms and signs....
Sotos syndrome
Sotos syndrome is a medical condition that may be associated with various symptoms and signs....
Spastic paraplegia-severe developmental delay-epilepsy syndrome
Spastic paraplegia-severe developmental delay-epilepsy syndrome is a medical condition that may be associated ...
Spinal muscular atrophy-progressive myoclonic epilepsy syndrome
Spinal muscular atrophy-progressive myoclonic epilepsy syndrome is a medical condition that may be associated ...
X-linked intellectual disability, Cantagrel type
An X-linked syndromic intellectual disability characterized by marked neonatal hypotonia, progressive quadripa...
branched-chain keto acid dehydrogenase kinase deficiency
A rare disorder of branched-chain amino acid metabolism characterized by childhood-onset epilepsy, autism and ...
developmental and epileptic encephalopathy 102
developmental and epileptic encephalopathy 102 is a medical condition that may be associated with various symp...
developmental and epileptic encephalopathy 119
A developmental and epileptic encephalopathy caused by the variants in the RNU2-2 gene, in which most reported...
developmental and epileptic encephalopathy 94
An idiopathic generalized epilepsy characterized by onset of multiple seizure types in the first few years of ...
developmental and epileptic encephalopathy, 2
Any early infantile epileptic encephalopathy in which the cause of the disease is a mutation in the CDKL5 gene...
developmental and epileptic encephalopathy, 63
developmental and epileptic encephalopathy, 63 is a medical condition that may be associated with various symp...
Tests providers may use to investigate generalized myoclonic seizure
When investigating generalized myoclonic seizure, a healthcare provider may order one or more of the following laboratory tests. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Fasting Glucose
Measures blood sugar after fasting to screen for diabetes and prediabetes....
Hemoglobin A1c (HbA1c)
Reflects average blood sugar over the past 2-3 months....
Magnesium
Measures magnesium levels, important for nerve and muscle function....
Thyroid Panel
Comprehensive thyroid testing including TSH, free T4, and free T3....
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Symptoms commonly seen alongside generalized myoclonic seizure
Dysphagia
Difficulty in swallowing....
Fatigue
A subjective feeling of tiredness characterized by a lack of energy and motivation....
Fever
Body temperature elevated above the normal range....
Headache
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve....
Muscle weakness
Reduced strength of muscles....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
When to seek care
Seek care from a qualified healthcare provider if generalized myoclonic seizure is severe, persistent, worsening, or accompanied by concerning symptoms. If you think you have a medical emergency, call your local emergency number immediately.
Frequently Asked Questions
What does the symptom generalized myoclonic seizure mean?
Generalized myoclonic seizure is a health sign or symptom described in medical literature. A generalized myoclonic seizure is a type of generalized motor seizure characterized by bilateral, sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.
Which conditions are associated with generalized myoclonic seizure?
Generalized myoclonic seizure has been reported in association with 48 conditions in the medical literature we index, including 3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form, Alacrimia-choreoathetosis-liver dysfunction syndrome, Angelman syndrome, Bilateral generalized polymicrogyria, Bilateral polymicrogyria. These associations do not mean you have any of these conditions.
Should I see a doctor about generalized myoclonic seizure?
You should discuss any persistent or concerning symptoms with a qualified healthcare provider. This website does not provide diagnosis. If you have severe symptoms or signs of a medical emergency, seek care immediately.