Fatigable weakness
A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
Also called: Fatigable weakness of limb muscles, Generalised muscle weakness due to defect at the neuromuscular junction, Generalized muscle weakness due to defect at the neuromuscular junction, Myasthenia, Myasthenic weakness, Proximal muscle weakness due to defect at the neuromuscular junction.
Conditions associated with fatigable weakness
The following conditions have been associated with fatigable weakness in medical literature. This is informational and not a diagnosis.
Autosomal dominant hypocalcemia
Autosomal dominant hypocalcemia is a medical condition that may be associated with various symptoms and signs....
Congenital myasthenic syndrome
Congenital myasthenic syndrome is a medical condition that may be associated with various symptoms and signs....
Immunodeficiency 126
Immunodeficiency 126 is a medical condition that may be associated with various symptoms and signs....
Medium chain acyl-CoA dehydrogenase deficiency
Medium chain acyl-CoA dehydrogenase deficiency is a medical condition that may be associated with various symp...
Optic pathway glioma
Optic pathway glioma is a medical condition that may be associated with various symptoms and signs....
Presynaptic congenital myasthenic syndromes
Presynaptic congenital myasthenic syndromes is a medical condition that may be associated with various symptom...
Pulmonary alveolar microlithiasis
Pulmonary alveolar microlithiasis is a medical condition that may be associated with various symptoms and sign...
Thymic carcinoma
Thymic carcinoma is a medical condition that may be associated with various symptoms and signs....
congenital myasthenic syndrome 1A
Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the CHRNA1 gene....
congenital myasthenic syndrome 20
Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the SLC5A7 gene....
congenital myasthenic syndrome 4A
A congenital myasthenic syndrome characterized by postsynaptic neuromuscular junction defects, early-onset pro...
congenital myasthenic syndrome 5
Congenital myasthenic syndrome caused by mutation(s) in the COLQ gene, encoding acetylcholinesterase collageni...
congenital myasthenic syndrome 6
Congenital myasthenic syndrome caused by mutation(s) in the CHAT gene, encoding choline O-acetyltransferase. I...
congenital myasthenic syndrome 9
Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the MUSK gene....
Tests providers may use to investigate fatigable weakness
When investigating fatigable weakness, a healthcare provider may order one or more of the following laboratory tests. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Symptoms commonly seen alongside fatigable weakness
Dysphagia
Difficulty in swallowing....
Fatigue
A subjective feeling of tiredness characterized by a lack of energy and motivation....
Fever
Body temperature elevated above the normal range....
Headache
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve....
Muscle weakness
Reduced strength of muscles....
Seizure
A seizure is an intermittent abnormality of nervous system physiology characterized by a transient occurrence ...
When to seek care
Seek care from a qualified healthcare provider if fatigable weakness is severe, persistent, worsening, or accompanied by concerning symptoms. If you think you have a medical emergency, call your local emergency number immediately.
Frequently Asked Questions
What does the symptom fatigable weakness mean?
Fatigable weakness is a health sign or symptom described in medical literature. A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.
Which conditions are associated with fatigable weakness?
Fatigable weakness has been reported in association with 14 conditions in the medical literature we index, including Autosomal dominant hypocalcemia, Congenital myasthenic syndrome, Immunodeficiency 126, Medium chain acyl-CoA dehydrogenase deficiency, Optic pathway glioma. These associations do not mean you have any of these conditions.
Should I see a doctor about fatigable weakness?
You should discuss any persistent or concerning symptoms with a qualified healthcare provider. This website does not provide diagnosis. If you have severe symptoms or signs of a medical emergency, seek care immediately.