Trazodone: Side Effects, Uses & Monitoring
Trazodone hydrochloride tablets are indicated for the treatment of depression.
- Data source
- FDA labeling via NIH DailyMed (label 911802e4…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
| Adverse reaction (as reported in labeling) | Reported frequency* |
|---|---|
| Drowsiness | 40.8% |
| Dry mouth | 33.8% |
| Dizziness/lightheadedness | 28% |
| Headache | 19.8% |
| Nervousness | 14.8% |
| Blurred vision | 14.7% |
| Nausea/vomiting | 12.7% |
| Insomnia | 12% |
| Fatigue | 11.3% |
| Constipation | 7.6% |
| Confusion | 7.6% |
| Skin condition/edema | 7% |
| Hypotension | 7% |
| Tachycardia/palpitations | 7% |
| Anger/hostility | 6.3% |
| Excitement | 5.7% |
| Abdominal/gastric disorder | 5.7% |
| Nasal/sinus congestion | 5.7% |
| Nightmares/vivid dreams | 5.7% |
| Weight loss | 5.7% |
*Highest percentage reported for the active moiety across placebo-controlled trial tables in current FDA labeling. Values reflect trial reporting, not your individual risk.
Labeled uses (from FDA prescribing information)
Trazodone hydrochloride tablets are indicated for the treatment of depression. The efficacy of trazodone has been demonstrated in both inpatient and outpatient settings and for depressed patients with and without prominent anxiety. The depressive illness of patients studied corresponds to the Major Depressive Episode criteria of the American Psychiatric Association's Diagnostic and Statistical Manual, III.a Major Depressive Episode implies a prominent and relatively persistent (nearly every day for at least two weeks) depressed or dysphoric mood that usually interferes with daily functioning, and includes at least four of the following eight symptoms: change in appetite, change in sleep, psychomotor agitation or retardation, loss of interest in usual activities or decrease in sexual drive, increased fatigability, feelings of guilt or worthlessness, slowed thinking or impaired concentration, and suicidal ideation or attempts.
Conditions associated with Trazodone in labeling
Anxiety Disorder
A group of mental health conditions characterized by excessive worry, fear, or nervousness that interferes wit...
Depression
A common but serious mood disorder causing persistent sadness, loss of interest, and changes in sleep, appetit...
Generalized Anxiety Disorder
Persistent, excessive worry about everyday situations that is difficult to control and interferes with daily l...
Frequently Asked Questions
What is Trazodone used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Trazodone?
The table above shows adverse reactions and the highest frequencies reported in placebo-controlled trials summarized in current FDA labeling for Trazodone. Individual risk varies.
Does Trazodone require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Trazodone.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.