Pilocarpine: Side Effects, Uses & Monitoring
Pilocarpine Hydrochloride Tablets are indicated for 1) the treatment of symptoms of dry mouth from salivary gland hypofunction caused by radiotherapy for cancer of the head and neck; and 2) the treatment of symptoms of d
- Data source
- FDA labeling via NIH DailyMed (label 610022b7…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
| Adverse reaction (as reported in labeling) | Reported frequency* |
|---|---|
| Sweating | 68% |
| Nausea | 15% |
| Chills | 15% |
| Rhinitis | 14% |
| Flushing | 13% |
| Urinary frequency | 12% |
| Dizziness | 12% |
| Asthenia | 12% |
| Headache | 11% |
| Flu syndrome | 9% |
| Diarrhea | 7% |
| Dyspepsia | 7% |
| Lacrimation | 6% |
| Edema | 5% |
| Abdominal pain | 4% |
| Amblyopia | 4% |
| Vomiting | 4% |
| Pain | 4% |
| Sinusitis | 4% |
| Pharyngitis | 3% |
*Highest percentage reported for the active moiety across placebo-controlled trial tables in current FDA labeling. Values reflect trial reporting, not your individual risk.
Labeled uses (from FDA prescribing information)
Pilocarpine Hydrochloride Tablets are indicated for 1) the treatment of symptoms of dry mouth from salivary gland hypofunction caused by radiotherapy for cancer of the head and neck; and 2) the treatment of symptoms of dry mouth in patients with Sjogren's Syndrome.
Frequently Asked Questions
What is Pilocarpine used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Pilocarpine?
The table above shows adverse reactions and the highest frequencies reported in placebo-controlled trials summarized in current FDA labeling for Pilocarpine. Individual risk varies.
Does Pilocarpine require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Pilocarpine.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.