Lubiprostone: Side Effects, Uses & Monitoring
1.1 Chronic Idiopathic Constipation in Adults Lubiprostone capsules are indicated for the treatment of chronic idiopathic constipation (CIC) in adults.
- Data source
- FDA labeling via NIH DailyMed (label f2121338…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
No structured frequency data available in current labeling. Consult the official label.
Labeled uses (from FDA prescribing information)
1.1 Chronic Idiopathic Constipation in Adults Lubiprostone capsules are indicated for the treatment of chronic idiopathic constipation (CIC) in adults. 1.2 Opioid-Induced Constipation in Adult Patients with Chronic Non-Cancer Pain Lubiprostone capsules are indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain, including patients with chronic pain related to prior cancer or its treatment who do not require frequent (e.g., weekly) opioid dosage escalation. Limitations of Use: Effectiveness of lubiprostone capsules in the treatment of opioid-induced constipation in patients taking diphenylheptane opioids (e.g., methadone) has not been established [see Clinical Studies (14.2)]. 1.3 Irritable Bowel Syndrome with Constipation Lubiprostone capsules are indicated for the treatment of irritable bowel syndrome with constipation (IBS-C) in women at least 18 years old.
Conditions associated with Lubiprostone in labeling
Constipation
Infrequent or difficult bowel movements, often caused by diet, dehydration, medications, or underlying conditi...
Irritable Bowel Syndrome
A common functional disorder of the gut causing abdominal pain, bloating, and changes in bowel habits such as ...
Irritable Bowel Syndrome - Constipation Predominant
A subtype of IBS characterized by constipation with abdominal pain and bloating....
Frequently Asked Questions
What is Lubiprostone used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Lubiprostone?
Current labeling for this ingredient does not include a structured frequency table that we can reproduce. Review the official label linked below.
Does Lubiprostone require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Lubiprostone.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.