Loteprednol: Side Effects, Uses & Monitoring
Loteprednol etabonate and tobramycin ophthalmic suspension, 0.5%/0.3% is a topical anti- infective and corticosteroid combination for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indica
- Data source
- FDA labeling via NIH DailyMed (label 7c752fac…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
No structured frequency data available in current labeling. Consult the official label.
Labeled uses (from FDA prescribing information)
Loteprednol etabonate and tobramycin ophthalmic suspension, 0.5%/0.3% is a topical anti- infective and corticosteroid combination for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists. Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and where the inherent risk of steroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns, or penetration of foreign bodies. The use of a combination drug with an anti-infective component is indicated where the risk of superficial ocular infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye. The particular anti-infective drug in this product (tobramycin) is active against the…
Conditions associated with Loteprednol in labeling
Conjunctivitis
Inflammation of the conjunctiva (pink eye) caused by infection or allergy, causing redness, itching, and disch...
Herpes Zoster
A painful rash (shingles) caused by reactivation of the varicella-zoster virus, often with burning pain before...
Rosacea
A chronic skin condition causing facial redness, flushing, and sometimes pimples or eye irritation....
Shingles
A painful rash caused by reactivation of the varicella-zoster virus, usually appearing as a band of blisters o...
Uveitis
Inflammation of the middle layer of the eye (uvea), causing eye pain, redness, and light sensitivity....
Frequently Asked Questions
What is Loteprednol used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Loteprednol?
Current labeling for this ingredient does not include a structured frequency table that we can reproduce. Review the official label linked below.
Does Loteprednol require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Loteprednol.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.