Lisinopril: Side Effects, Uses & Monitoring
Lisinopril and hydrochlorothiazide tablets are indicated for the treatment of hypertension.
- Data source
- FDA labeling via NIH DailyMed (label 7cd68095…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
| Adverse reaction (as reported in labeling) | Reported frequency* |
|---|---|
| Headache | 19% |
| Diarrhea | 2.4% |
| Nausea | 2.4% |
| Dizziness | 1.9% |
| Cough | 1% |
| Fatigue | 1% |
| Orthostatic effects | 1% |
| Asthenia | 1% |
| Muscle cramps | 0.5% |
| Hypotension | 0.5% |
| Vomiting | 0.5% |
| Rash | 0.5% |
| Upper respiratory infection | 0% |
| Paresthesia | 0% |
| Dyspepsia | 0% |
| Impotence | 0% |
*Highest percentage reported for the active moiety across placebo-controlled trial tables in current FDA labeling. Values reflect trial reporting, not your individual risk.
Labeled uses (from FDA prescribing information)
Lisinopril and hydrochlorothiazide tablets are indicated for the treatment of hypertension. These fixed-dose combinations are not indicated for initial therapy (see DOSAGE AND ADMINISTRATION ). In using lisinopril and hydrochlorothiazide tablets, consideration should be given to the fact that an angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that lisinopril does not have a similar risk. (See WARNINGS .) In considering use of lisinopril and hydrochlorothiazide tablets, it should be noted that Black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-Blacks. (See WARNINGS, Head and Neck Angioedema .)
Tests providers may use to monitor Lisinopril therapy
Conditions associated with Lisinopril in labeling
Frequently Asked Questions
What is Lisinopril used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Lisinopril?
The table above shows adverse reactions and the highest frequencies reported in placebo-controlled trials summarized in current FDA labeling for Lisinopril. Individual risk varies.
Does Lisinopril require lab monitoring?
Labeling and standard practice associate Lisinopril with periodic laboratory monitoring; the tests above are commonly ordered by clinicians to monitor patients on therapy. Your provider decides what is appropriate.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.