Levoleucovorin: Side Effects, Uses & Monitoring
Levoleucovorin for Injection is indicated for: rescue after high-dose methotrexate therapy in adult and pediatric patients with osteosarcoma.
- Data source
- FDA labeling via NIH DailyMed (label 54f01988…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
No structured frequency data available in current labeling. Consult the official label.
Labeled uses (from FDA prescribing information)
Levoleucovorin for Injection is indicated for: rescue after high-dose methotrexate therapy in adult and pediatric patients with osteosarcoma. diminishing the toxicity associated with overdosage of folic acid antagonists or impaired methotrexate elimination in adult and pediatric patients. the treatment of adults with metastatic colorectal cancer in combination with fluorouracil. Limitations of Use Levoleucovorin for Injection is not indicated for pernicious anemia and megaloblastic anemia secondary to the lack of vitamin B12, because of the risk of progression of neurologic manifestations despite hematologic remission.
Conditions associated with Levoleucovorin in labeling
Anemia
A condition in which the blood has a lower than normal number of red blood cells or hemoglobin, reducing oxyge...
Colon Cancer
Cancer of the colon or rectum, often developing from polyps, which can cause changes in bowel habits and blood...
Colorectal Cancer
Cancer of the colon or rectum. Screening can detect it early when treatment is most effective....
Vitamin B12 Deficiency
Insufficient vitamin B12 can cause anemia and neurological symptoms including numbness, tingling, balance prob...
Frequently Asked Questions
What is Levoleucovorin used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Levoleucovorin?
Current labeling for this ingredient does not include a structured frequency table that we can reproduce. Review the official label linked below.
Does Levoleucovorin require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Levoleucovorin.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.