Leucovorin: Side Effects, Uses & Monitoring
Leucovorin Calcium, USP rescue is indicated after high dose methotrexate therapy in osteosarcoma.
- Data source
- FDA labeling via NIH DailyMed (label cc52077f…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
| Adverse reaction (as reported in labeling) | Reported frequency* |
|---|---|
| Leukopenia | 93% |
| Stomatitis | 84% |
| Nausea | 80% |
| Diarrhea | 67% |
| Vomiting | 46% |
| Alopecia | 43% |
| Dermatitis | 25% |
| Anorexia | 22% |
| Thrombocytopenia | 18% |
| Hospitalization for toxicity | 15% |
| Lethargy/malaise/fatigue | 13% |
| Infection | 8% |
| Constipation | 4% |
*Highest percentage reported for the active moiety across placebo-controlled trial tables in current FDA labeling. Values reflect trial reporting, not your individual risk.
Labeled uses (from FDA prescribing information)
Leucovorin Calcium, USP rescue is indicated after high dose methotrexate therapy in osteosarcoma. Leucovorin Calcium, USP is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosages of folic acid antagonists. Leucovorin Calcium, USP is indicated in the treatment of megaloblastic anemias due to folic acid deficiency when oral therapy is not feasible. Leucovorin Calcium, USP is also indicated for use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer. Leucovorin should not be mixed in the same infusion as 5-fluorouracil because a precipitate may form.
Conditions associated with Leucovorin in labeling
Frequently Asked Questions
What is Leucovorin used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Leucovorin?
The table above shows adverse reactions and the highest frequencies reported in placebo-controlled trials summarized in current FDA labeling for Leucovorin. Individual risk varies.
Does Leucovorin require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Leucovorin.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.