Indomethacin: Side Effects, Uses & Monitoring
Carefully consider the potential benefits and risks of indomethacin extended-release capsules and other treatment options before deciding to use indomethacin extended-release capsules.
- Data source
- FDA labeling via NIH DailyMed (label dfdcdb27…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
No structured frequency data available in current labeling. Consult the official label.
Labeled uses (from FDA prescribing information)
Carefully consider the potential benefits and risks of indomethacin extended-release capsules and other treatment options before deciding to use indomethacin extended-release capsules. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Indomethacin extended-release capsules have been found effective in active stages of the following: 1. Moderate to severe rheumatoid arthritis including acute flares of chronic disease. 2. Moderate to severe ankylosing spondylitis. 3. Moderate to severe osteoarthritis. 4. Acute painful shoulder (bursitis and/or tendinitis). Indomethacin extended-release capsules, USP are not recommended for the treatment of acute gouty arthritis. Indomethacin may enable the reduction of steroid dosage in patients receiving steroids for the more severe forms of rheumatoid arthritis. In such instances the steroid dosage should be reduced slowly and the patients followed very closely for any possible adverse effects. The use of indomethacin in conjunction with aspirin or other salicylates is not recommended. Controlled clinical studies have shown that the combined use of indomethacin and aspirin do…
Conditions associated with Indomethacin in labeling
Ankylosing Spondylitis
A chronic inflammatory disease primarily affecting the spine and sacroiliac joints, causing back pain and stif...
Bursitis
Inflammation of the fluid-filled sacs (bursae) that cushion joints, causing pain and swelling, often in the sh...
Gout
A form of arthritis caused by uric acid crystal deposition, causing sudden severe joint pain, often in the big...
Osteoarthritis
The most common form of arthritis, caused by wear and tear of joint cartilage, leading to pain, stiffness, and...
Rheumatoid Arthritis
A chronic autoimmune disease causing inflammation of joints, leading to pain, swelling, stiffness, and joint d...
Frequently Asked Questions
What is Indomethacin used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Indomethacin?
Current labeling for this ingredient does not include a structured frequency table that we can reproduce. Review the official label linked below.
Does Indomethacin require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Indomethacin.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.