Hydroxocobalamin: Side Effects, Uses & Monitoring
Pernicious anemia, both uncomplicated and accompanied by nervous system involvement.
- Data source
- FDA labeling via NIH DailyMed (label 17e7d7d8…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
No structured frequency data available in current labeling. Consult the official label.
Labeled uses (from FDA prescribing information)
Pernicious anemia, both uncomplicated and accompanied by nervous system involvement. Dietary deficiency of Vitamin B12 , occurring in strict vegetarians and in their breast-fed infants. (Isolated vitamin B12 deficiency is very rare). Malabsorption of vitamin B12 , resulting from structural or functional damage to the stomach, where intrinsic factor is secreted or to the ileum, where intrinsic factor facilitates vitamin B12 absorption. These conditions include tropical sprue, and nontropical sprue (idiopathic steatorrhea, gluten-induced enteropathy). Folate deficiency in these patients is usually more severe than vitamin B12 deficiency. Inadequate secretion of intrinsic factor, resulting from lesions that destroy the gastric mucosa (ingestion of corrosives, extensive neoplasia), and a number of conditions associated with a variable degree of gastric atrophy (such as multiple sclerosis, certain endocrine disorders, iron deficiency, and subtotal gastrectomy). Total gastrectomy always produces vitamin B12 deficiency. Structural lesions leading to vitamin B12 deficiency include regional ileitis, ileal resections, malignancies, etc. Competition for Vitamin B12 by intestinal parasites or …
Conditions associated with Hydroxocobalamin in labeling
Anemia
A condition in which the blood has a lower than normal number of red blood cells or hemoglobin, reducing oxyge...
Iron Deficiency
A common cause of anemia in which the body lacks enough iron to make hemoglobin. It can result from blood loss...
Multiple Sclerosis
A chronic autoimmune disease that damages the myelin sheath of nerves, causing a wide range of neurological sy...
Vitamin B12 Deficiency
Insufficient vitamin B12 can cause anemia and neurological symptoms including numbness, tingling, balance prob...
Frequently Asked Questions
What is Hydroxocobalamin used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Hydroxocobalamin?
Current labeling for this ingredient does not include a structured frequency table that we can reproduce. Review the official label linked below.
Does Hydroxocobalamin require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Hydroxocobalamin.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.