Escitalopram: Side Effects, Uses & Monitoring
1.1 Major Depressive Disorder Lexapro (escitalopram) is indicated for the acute and maintenance treatment of major depressive disorder in adults and in adolescents 12 to 17 years of age [see Clinical Studies (14.1 ) ].
- Data source
- FDA labeling via NIH DailyMed (label 23ff2d62…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
| Adverse reaction (as reported in labeling) | Reported frequency* |
|---|---|
| Headache | 24% |
| Nausea | 15% |
| Insomnia | 9% |
| Ejaculation disorder | 9% |
| Diarrhea | 8% |
| Dry mouth | 6% |
| Somnolence | 6% |
| Sweating increased | 5% |
| Dizziness | 5% |
| Influenza-like symptoms | 5% |
| Fatigue | 5% |
| Rhinitis | 5% |
| Constipation | 3% |
| Indigestion | 3% |
| Appetite decreased | 3% |
| Libido decreased | 3% |
| Sinusitis | 3% |
| Impotence | 3% |
| Vomiting | 3% |
| Neck/shoulder pain | 3% |
*Highest percentage reported for the active moiety across placebo-controlled trial tables in current FDA labeling. Values reflect trial reporting, not your individual risk.
Labeled uses (from FDA prescribing information)
1.1 Major Depressive Disorder Lexapro (escitalopram) is indicated for the acute and maintenance treatment of major depressive disorder in adults and in adolescents 12 to 17 years of age [see Clinical Studies (14.1 ) ]. A major depressive episode (DSM-IV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed or dysphoric mood that usually interferes with daily functioning, and includes at least five of the following nine symptoms: depressed mood, loss of interest in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt or suicidal ideation. 1.2 Generalized Anxiety DisorderLexapro is indicated for the acute treatment of Generalized Anxiety Disorder (GAD) in adults [see Clinical Studies (14.2 ) ]. Generalized Anxiety Disorder (DSM-IV) is characterized by excessive anxiety and worry (apprehensive expectation) that is persistent for at least 6 months and which the person finds difficult to control. It must be associated with at least 3 of the following sympt…
Tests providers may use to monitor Escitalopram therapy
Conditions associated with Escitalopram in labeling
Anxiety Disorder
A group of mental health conditions characterized by excessive worry, fear, or nervousness that interferes wit...
Depression
A common but serious mood disorder causing persistent sadness, loss of interest, and changes in sleep, appetit...
Generalized Anxiety Disorder
Persistent, excessive worry about everyday situations that is difficult to control and interferes with daily l...
Insomnia
Difficulty falling asleep, staying asleep, or getting restful sleep despite adequate opportunity, affecting da...
Frequently Asked Questions
What is Escitalopram used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Escitalopram?
The table above shows adverse reactions and the highest frequencies reported in placebo-controlled trials summarized in current FDA labeling for Escitalopram. Individual risk varies.
Does Escitalopram require lab monitoring?
Labeling and standard practice associate Escitalopram with periodic laboratory monitoring; the tests above are commonly ordered by clinicians to monitor patients on therapy. Your provider decides what is appropriate.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.