Bupropion: Side Effects, Uses & Monitoring
Major Depressive Disorder: Bupropion hydrochloride extended-release tablets (XL) are indicated for the treatment of major depressive disorder.
- Data source
- FDA labeling via NIH DailyMed (label 0bff4522…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
| Adverse reaction (as reported in labeling) | Reported frequency* |
|---|---|
| Headache | 34% |
| Dry mouth | 26% |
| Insomnia | 20% |
| Nausea | 13% |
| Nasopharyngitis | 13% |
| Constipation | 9% |
| Infection | 9% |
| Anxiety | 7% |
| Flatulence | 6% |
| Dizziness | 6% |
| Sinusitis | 5% |
| Cough | 4% |
| Decreased appetite | 4% |
| Tremor | 3% |
| Abnormal dreams | 3% |
| Myalgia | 3% |
| Pain in extremity | 3% |
| Feeling jittery | 3% |
| Rash | 3% |
| Tinnitus | 3% |
*Highest percentage reported for the active moiety across placebo-controlled trial tables in current FDA labeling. Values reflect trial reporting, not your individual risk.
Labeled uses (from FDA prescribing information)
Major Depressive Disorder: Bupropion hydrochloride extended-release tablets (XL) are indicated for the treatment of major depressive disorder. The efficacy of bupropion in the treatment of a major depressive episode was established in two 4-week controlled trials of inpatients and in one 6-week controlled trial of outpatients whose diagnoses corresponded most closely to the Major Depression category of the APA Diagnostic and Statistical Manual (DSM) (see CLINICAL TRIALS ). A major depressive episode (DSM-IV) implies the presence of 1) depressed mood or 2) loss of interest or pleasure; in addition, at least 5 of the following symptoms have been present during the same 2-week period and represent a change from previous functioning: depressed mood, markedly diminished interest or pleasure in usual activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, a suicide attempt, or suicidal ideation. The efficacy of bupropion in maintaining an antidepressant response for up to 44 weeks following 8 weeks of acute treatment was demons…
Conditions associated with Bupropion in labeling
Depression
A common but serious mood disorder causing persistent sadness, loss of interest, and changes in sleep, appetit...
Insomnia
Difficulty falling asleep, staying asleep, or getting restful sleep despite adequate opportunity, affecting da...
Seasonal Affective Disorder
A type of depression related to changes in seasons, typically occurring in fall and winter....
Frequently Asked Questions
What is Bupropion used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Bupropion?
The table above shows adverse reactions and the highest frequencies reported in placebo-controlled trials summarized in current FDA labeling for Bupropion. Individual risk varies.
Does Bupropion require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Bupropion.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.