Alprazolam: Side Effects, Uses & Monitoring
INDICATIONS AND USAGEAlprazolam tablets are indicated for the management of anxiety disorder (a condition corresponding most closely to the APA Diagnostic and Statistical Manual (DSM-III-R) diagnosis of generalized anxie
- Data source
- FDA labeling via NIH DailyMed (label 6224f2c5…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
| Adverse reaction (as reported in labeling) | Reported frequency* |
|---|---|
| Fatigue and tiredness | 48.6% |
| Drowsiness | 41% |
| Impaired coordination | 40.1% |
| Light-headedness/dizziness | 36.9% |
| Decreased salivation | 34.2% |
| Irritability | 33.1% |
| Memory impairment | 33.1% |
| Increased | 32.7% |
| Cognitive disorder | 28.8% |
| Decreased appetite | 27.8% |
| Tachycardia | 26.8% |
| Wbc/hpf | 25.9% |
| Anxiety | 24.9% |
| Sweating | 23.5% |
| Dysarthria | 23.3% |
| Abdominal distress | 21.5% |
| Light-headedness | 20.8% |
| Headache | 19.6% |
| Insomnia | 18.4% |
| Depression | 18.1% |
*Highest percentage reported for the active moiety across placebo-controlled trial tables in current FDA labeling. Values reflect trial reporting, not your individual risk.
Labeled uses (from FDA prescribing information)
INDICATIONS AND USAGEAlprazolam tablets are indicated for the management of anxiety disorder (a condition corresponding most closely to the APA Diagnostic and Statistical Manual (DSM-III-R) diagnosis of generalized anxiety disorder) or the short-term relief of symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. Generalized anxiety disorder is characterized by unrealistic or excessive anxiety and worry (apprehensive expectation) about two or more life circumstances, for a period of six months or longer, during which the person has been bothered more days than not by these concerns. At least 6 of the following 18 symptoms are often present in these patients: Motor Tension (trembling, twitching, or feeling shaky; muscle tension, aches, or soreness; restlessness; easy fatigability); Autonomic Hyperactivity (shortness of breath or smothering sensations; palpitations or accelerated heart rate; sweating, or cold clammy hands; dry mouth; dizziness or light-headedness; nausea, diarrhea, or other abdominal distress; flushes or chills; frequent urination; trouble swallowing or ‘lump in throat’); Vigilance a…
Conditions associated with Alprazolam in labeling
Anxiety Disorder
A group of mental health conditions characterized by excessive worry, fear, or nervousness that interferes wit...
Dizziness
A feeling of lightheadedness, unsteadiness, or spinning, which can have many causes....
Generalized Anxiety Disorder
Persistent, excessive worry about everyday situations that is difficult to control and interferes with daily l...
Palpitations
The sensation of a racing, pounding, fluttering, or irregular heartbeat....
Shortness of Breath
A feeling of being unable to catch your breath or get enough air, which can be sudden or gradual....
Vertigo
The sensation of spinning or movement when still, often due to inner ear or neurological conditions....
Frequently Asked Questions
What is Alprazolam used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of Alprazolam?
The table above shows adverse reactions and the highest frequencies reported in placebo-controlled trials summarized in current FDA labeling for Alprazolam. Individual risk varies.
Does Alprazolam require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking Alprazolam.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.