4-Hydroxycyclophosphamide: Side Effects, Uses & Monitoring
Malignant Diseases Cyclophosphamide Injection is indicated for the treatment of adult patients with: • malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin’s lymphoma, lymphocytic lymphoma (no
- Data source
- FDA labeling via NIH DailyMed (label cf2f4b95…)
- Label version
- current
- Last reviewed
- 2026
Reported adverse reactions
Reactions listed in current FDA labeling, with the highest frequency reported across summarized placebo-controlled trials.
No structured frequency data available in current labeling. Consult the official label.
Labeled uses (from FDA prescribing information)
Malignant Diseases Cyclophosphamide Injection is indicated for the treatment of adult patients with: • malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin’s lymphoma, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt’s lymphoma • multiple myeloma • leukemias: Chronic lymphocytic leukemia, chronic granulocytic leukemia (it is usually ineffective in acute blastic crisis), acute myelogenous and monocytic leukemia, acute lymphoblastic (stem-cell) leukemia (cyclophosphamide given during remission is effective in prolonging its duration) • mycosis fungoides (advanced disease) • neuroblastoma (disseminated disease) • adenocarcinoma of the ovary • retinoblastoma • carcinoma of the breast Cyclophosphamide, although effective alone in susceptible malignancies, is more frequently used concurrently or sequentially with other antineoplastic drugs. Limitations of Use This cyclophosphamide product is not indicated for use in pediatric patients due to the to the alcohol and propylene glycol content in this product. If treatment with cyclophosphamide is indicated in a pediatric patient, use a different cyclophosphamide pr…
Conditions associated with 4-Hydroxycyclophosphamide in labeling
Leukemia
Cancer of the blood-forming tissues, causing abnormal blood cells that can lead to anemia, infection, and blee...
Lymphoma
Cancer of the lymphatic system, causing swollen lymph nodes, fever, night sweats, and weight loss....
Neuroblastoma
Neuroblastoma is a medical condition that may be associated with various symptoms and signs....
Frequently Asked Questions
What is 4-Hydroxycyclophosphamide used for?
FDA labeling lists the approved uses shown above under "Labeled uses." This summary is informational; only a qualified prescriber can determine whether a medication is appropriate for you.
What are the most commonly reported side effects of 4-Hydroxycyclophosphamide?
Current labeling for this ingredient does not include a structured frequency table that we can reproduce. Review the official label linked below.
Does 4-Hydroxycyclophosphamide require lab monitoring?
Monitoring needs vary. Ask your healthcare provider whether any lab tests apply while taking 4-Hydroxycyclophosphamide.
Where does this information come from?
All clinical facts on this page were extracted from the current FDA-registered product labeling for this ingredient, published by manufacturers through NIH DailyMed. See the source link below.
Medical disclaimer: Educational content extracted from public FDA labeling. Not medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.