Muckle-Wells syndrome
An intermediate form of cryopyrin-associated periodic syndrome (CAPS) and is characterized by recurrent fever (with malaise and chills), recurrent urticaria-like skin rash, sensorineural deafness, general signs of inflammation (eye redness, headaches, arthralgia/myalgia) and potentially life-threatening secondary amyloidosis (AA type).
Also known as: Muckle-Wells syndrome, neutrophilic urticaria, MWS, Muckle Wells syndrome, urticaria, deafness and amyloidosis.
Category: General
Symptoms associated with Muckle-Wells syndrome
The following symptoms have been associated with Muckle-Wells syndrome in medical literature. Not everyone experiences the same symptoms.
Arthralgia
Joint pain....
Chronic fatigue
Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months ...
Conjunctival hyperemia
Dilatation of the blood vessels of the conjunctiva leading to a red appearance of the sclera....
Headache
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve....
Hearing impairment
A decreased magnitude of the sensory perception of sound....
Myalgia
Pain in muscle....
Progressive sensorineural hearing impairment
A progressive form of sensorineural hearing impairment....
Recurrent fever
Periodic (episodic or recurrent) bouts of fever....
Urticaria
Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intens...
Tests used to investigate Muckle-Wells syndrome
Healthcare providers may order these tests when evaluating Muckle-Wells syndrome. Test selection is a clinical decision made by a qualified professional.
CBC with Differential
Measures red blood cells, white blood cells, and platelets to help evaluate overall health and detect disorder...
Comprehensive Metabolic Panel (CMP)
Measures 14 substances in the blood to assess kidney and liver function, electrolyte balance, and blood sugar ...
Urinalysis
Examines urine content to help detect urinary tract infections, kidney disease, and diabetes....
Conditions with overlapping symptoms
These conditions share symptoms with Muckle-Wells syndrome, which is why a clinical evaluation is important.
Behçet disease
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TNF receptor 1-associated periodic fever syndrome
A periodic fever syndrome, characterized by recurrent fever, arthralgia, myalgia and tender skin lesions lasti...
familial cold autoinflammatory syndrome 1
Any familial cold autoinflammatory syndrome in which the cause of the disease is a mutation in the NLRP3 gene....
familial cold autoinflammatory syndrome 2
An autoinflammatory disease caused by mutations in the NLRP12 gene. It is characterized by periodic fevers beg...
Frequently Asked Questions
What is Muckle-Wells syndrome?
Muckle-Wells syndrome is a health condition described in medical literature. An intermediate form of cryopyrin-associated periodic syndrome (CAPS) and is characterized by recurrent fever (with malaise and chills), recurrent urticaria-like skin rash, sensorineural deafness, general signs of inflammation (eye redness, headaches, arthralgia/myalgia) and potentially life-threatening secondary amyloidosis (AA type).
What are the symptoms of Muckle-Wells syndrome?
Muckle-Wells syndrome is associated with 9 symptoms in the medical literature we index, including Arthralgia, Chronic fatigue, Conjunctival hyperemia, Headache, Hearing impairment, Myalgia. Symptoms vary widely between individuals.
How is Muckle-Wells syndrome diagnosed or investigated?
A healthcare provider may use a combination of medical history, physical examination, and tests. Common tests associated with Muckle-Wells syndrome include CBC with Differential, Comprehensive Metabolic Panel (CMP), Urinalysis. This information is educational, not a diagnosis.
Is SymptomDatabase.com diagnosing me?
No. SymptomDatabase.com does not provide diagnosis. If you are concerned you may have Muckle-Wells syndrome, please discuss your symptoms with a qualified healthcare provider.